All-virtuous Herbert! on whose every part
Truth might spend all her voice, fame all her art!—
was a smoker, as we know from a very curious passage in his well-known autobiography. He appears to have smoked not so much for pleasure as for supposed reasons of health. "It is well known," he wrote, "to those that wait in my chamber, that the shirts, waistcoats, and other garments I wear next my body, are sweet, beyond what either can easily be believed, or hath been observed in any else, which sweetness also was found to be in my breath above others, before I used to take tobacco, which towards my latter time I was forced to take against certain rheums and catarrhs that trouble me, which yet did not taint my breath for any long time." The autobiography was written about 1645, so as Lord Herbert did not smoke till towards the latter part of his life—he died in 1648—he clearly was not one of those who took to tobacco in the first enthusiasm for the new indulgence.

From Chapter 5:
The belief in the prophylactic power of tobacco was, however, very generally held. When Mr. Samuel Pepys on June 7, 1665, for the first time saw several houses marked with the ominous red cross, and the words "Lord, have mercy upon us" chalked upon the doors, he felt so ill at ease that he was obliged to buy some roll tobacco to smell and chew. There is nothing to show that Pepys even smoked, which considering his proficiency in the arts of good-fellowship, is perhaps a little surprising. Defoe, in his fictitious but graphic "Journal of the Plague Year in London," says that the sexton of one of the London parishes, who personally handled a large number of the victims, never had the distemper at all, but lived about twenty years after it, and was sexton of the parish to the time of his death. This man, according to Defoe, "never used any preservative against the infection other than holding garlic and rue in his mouth, and smoking tobacco."