From Chapter 1:
Another tradition gives the old Pied Bull at Islington, long since demolished, as the scene of the momentous event. It is said in its earlier days to have been a country house of Sir Walter's, and according to legend it was in his dining-room in this house that he had his first pipe. Hone, in the first volume of the "Every Day Book" tells how he and some friends visited this Pied Bull, then in a very decayed condition, and smoked their pipes in the dining-room in memory of Sir Walter. From the recently published biography of William Hone by Mr. F.W. Hackwood, we learn that the jovial party consisted of William Hone, George Cruikshank, Joseph Goodyear, and David Sage, who jointly signed a humorous memorandum of their proceedings on the occasion, from which it appears that "each of us smoked a pipe, that is to say, each of us one or more pipes, or less than one pipe, and the undersigned George Cruikshank having smoked pipes innumerable or more or less," and that "several pots of porter, in aid of the said smoking," were consumed, followed by bowls of negus made from "port wine @ 3s. 6d. per bottle (duty knocked off lately)" and other ingredients. Speeches were made and toasts proposed, and altogether the four, who desired to "have the gratification of saying hereafter that we had smoked a pipe in the same room that the man who first introduced tobacco smoked in himself," seem to have thoroughly enjoyed themselves.

From Chapter 5:
At the time of the Great Plague all kinds of nostrums were sold and recommended as preservatives or as cures. Most of these perished with the occasion that called them forth; but the names of some have been preserved in a rare quarto tract which was published in the Plague year, 1665, entitled "A Brief Treatise of the Nature, Causes, Signes, Preservation from and Cure of the Pestilence," "collected by W. Kemp, Mr. of Arts." In the list of devices for purifying infected air it is stated that "The American Silver-weed, or Tobacco, is very excellent for this purpose, and an excellent defence against bad air, being smoked in a pipe, either by itself, or with Nutmegs shred, and Rew Seeds mixed with it, especially if it be nosed"—which, I suppose, means if the smoke be exhaled through the nose—"for it cleanseth the air, and choaketh, suppresseth and disperseth any venomous vapour." Mr. Kemp warms to his subject and proceeds with a whole-hearted panegyric that must be quoted in full: "It hath singular and contrary effects, it is good to warm one being cold, and will cool one being hot. All ages, all Sexes, all Constitutions, Young and Old, Men and Women, the Sanguine, the Cholerick, the Melancholy, the phlegmatick, take it without any manifest inconvenience, it quencheth thirst, and yet will make one more able, and fit to drink; it abates hunger, and yet will get one a good stomach; it is agreeable with mirth or sadness, with feasting and with fasting; it will make one rest that wants sleep, and will keep one waking that is drowsie; it hath an offensive smell to some, and is more desirable than any perfume to others; that it is a most excellent preservative, both experience and reason do teach; it corrects the air by Fumigation, and it avoids corrupt humours by Salivation; for when one takes it either by Chewing it in the leaf, or Smoaking it in the pipe, the humors are drawn and brought from all parts of the body, to the stomach, and from thence rising up to the mouth of the Tobacconist, as to the helme of a Sublimatory, are voided and spitten out."